ALTERATION OF HIGH-AFFINITY GLUTAMATE TRANSPORTERS IN AMYOTROPHIC LATERAL SCLEROSIS: ROLE OF OXIDATIVE STRESS AND NEUROPATHOLOGICAL SIGNIFICANCE

Pubblicazioni Scientifiche

• 1996 EUROPEAN JOURNAL OF NEUROSCIENCE

  The competitive transport inhibitor L-trans-pyrrolidine-2,4-dicarboxylate triggers excitotoxicity in rat cortical neuron-astrocyte co-cultures via glutamate release rather than uptake inhibition

• 1997 EUROPEAN JOURNAL OF NEUROSCIENCE

  Neuronal and glial glutamate transporters possess an SH-based redox regulatory mechanism

• 1998 TRENDS IN PHARMACOLOGICAL SCIENCES

  Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration?

• 1997 EUROPEAN JOURNAL OF NEUROSCIENCE

  Differential modulation of the uptake currents by redox interconversion of cysteine residues in the human neuronal glutamate transporter EAAC1

• 1997 EUROPEAN JOURNAL OF NEUROSCIENCE

  Non-synaptic localization of the glutamate transporter EAAC1 in cultured hippocampal neurons

• 1999 NATURE NEUROSCIENCE

  SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter

• 1996 JOURNAL OF BIOLOGICAL CHEMISTRY

  Peroxynitrite inhibits glutamate transporter subtypes

• 1999 CELLULAR AND MOLECULAR LIFE SCIENCES

  The active role of astrocytes in synaptic transmission

• 2001 NATURE NEUROSCIENCE

  CXCR4-activated astrocyte glutamate release via TNFa: amplification by microglia triggers neurotoxicity