ANALYSIS OF APOPTOSIS IN NEURODEGENERATIVE DISEASES BY APAF1 CONDITIONAL MUTAGENESIS

Pubblicazioni Scientifiche

• 2001 CELLULAR AND MOLECULAR LIFE SCIENCES

  Apaf1 in developmental apoptosis and cancer: how many ways to die?

• 2006 JOURNAL OF BIOLOGICAL CHEMISTRY

  Endoplasmic reticulum stress induces apoptosis by an apoptosome-dependent but caspase 12-independent mechanism

• 2002 NATURE NEUROSCIENCE

  Glial cells generate neurons: the role of the transcription factor Pax6

• 2002 JOURNAL OF CELL BIOLOGY

  Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

• 2005 SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

  Expanding roles of programmed cell death in mammalian neurodevelopment

• 2003 JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

  Physiological and pathological roles of Apaf1 and the apoptosome

• 2002 NATURE

  Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

• 2005 DEVELOPMENTAL DYNAMICS

  Localization of Apafl1 gene expression in the early development of the mouse by means of in situ reverse transcriptase-polymerase chain reaction

• 2002 CELL DEATH AND DIFFERENTIATION

  Apaf1 reduced expression levels generate a mutant phenotype in adult brain and skeleton

• 2004 CELL DEATH AND DIFFERENTIATION

  Apoptosome inactivation rescues proneural and neural cells from neurodegeneration

• 2003 JOURNAL OF NEUROSCIENCE RESEARCH

  Caspase regulation of genotoxin-induced neural precursor cell death

• 2001 JOURNAL OF CELL BIOLOGY

  APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death

• 2001 CELL DEATH AND DIFFERENTIATION

  Apaf1 is no longer single

• 2002 JOURNAL OF CELL SCIENCE

  Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death?

• 2004 DEVELOPMENT

  Apaf1-dependent programmed cell death is required for inner ear morphogenesis and growth

• 2008 NATURE CELL BIOLOGY

  Regulation of autophagy by cytoplasmic p53