ANALYSIS OF TRANSMEMBRANE SIGNALING IN HUMAN IMMUNODEFICIENCY DISEASES: ROLE OF CD38 AND RELATED SURFACE RECEPTORS

Pubblicazioni Scientifiche

• 1998 JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS

  Analysis of the distribution of human CD38 and of its ligand CD31 in normal tissues

• 2001 DIABETES

  Autoantibody response to CD38 in Caucasian patients with type 1 and type 2 diabetes - Immunological and genetic characterization

• 2001 FASEB JOURNAL

  Human CD38 and its ligand CD31 define a unique lamina propria T lymphocyte signaling pathway

• 1999 JOURNAL OF LEUKOCYTE BIOLOGY

  The metamorphosis of a molecule: from soluble enzyme to the leukocyte receptor CD38

• 1999 JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS

  Human CD38, a surface receptor, an enzyme, an adhesion molecule and not a simple marker

• 1998 BIOCHEMICAL JOURNAL

  CD38 binding to human myeloid cells is mediated by mouse and human CD31

• 1999 JOURNAL OF IMMUNOLOGY

  CD38 stimulation lowers the activation threshold and enhances the alloreactivity of cord blood T cells by activating the phosphatidylinositol 3-kinase pathway and inducing CD73 expression

• 1998 JOURNAL OF IMMUNOLOGY

  Role of CD38 and its ligand in the regulation of MHC-nonrestricted cytotoxic T cells

• 1998 JOURNAL OF CLINICAL INVESTIGATION

  Characterization of a CD38-like 78-kilodalton soluble protein released from B cell lines derived from patients with X-linked agammaglobulinemia

• 1999 IMMUNOGENETICS

  The human CD38 gene: polymorphism, CpG island, and linkage to the CD157 (BST-1) gene

• 2000 AIDS

  Role of CD38 in HIV-1 infection: an epiphenomenon of T-cell activation or an active player in virus/host interactions?

• 1998 JOURNAL OF IMMUNOLOGY

  Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member

• 1999 Blood

  CD38 triggers cytotoxic responses in activated human natural killer cells

• 2000 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME

  CD38 expressed on human monocytes: A coaccessory molecule in the superantigen-induced proliferation

• 2001 JOURNAL OF LEUKOCYTE BIOLOGY

  CD38 expression and functional activities are up-regulated by IFN-gamma on human monocytes and monocytic cell lines

• 1998 FASEB JOURNAL

  CD38 is functionally dependent on the TCR/CD3 complex in human T cells

• 2003 JOURNAL OF BIOLOGICAL CHEMISTRY

  CD38 signaling in T cells is initiated within a subset of membrane rafts containing Lck and the CD3-zeta subunit of the T cell antigen receptor

• 1999 JOURNAL OF BIOLOGICAL CHEMISTRY

  The CD3-gamma delta epsilon transducing module mediates CD38-induced protein-tyrosine kinase and mitogen-activated protein kinase activation in Jurkat T cells

• 2002 JOURNAL OF BIOLOGICAL CHEMISTRY

  CD38 is associated with lipid rafts and upon receptor stimulation leads to Akt/protein kinase B and Erk activation in the absence of the CD3-zeta immune receptor tyrosine-based activation motifs

• 1999 DIABETES

  Autoantibodies to CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) in Caucasian patients with diabetes - Effects on insulin release from human islets

• 1998 FEBS LETTERS

  Ectocellular CD38-catalyzed synthesis and intracellular Ca2+-signalling activity of cyclic ADP-ribose in T-lymphocytes are not functionally related

• 1998 JOURNAL OF IMMUNOLOGY

  CD38 functions are regulated through an internalization step

• 2001 INTERNATIONAL IMMUNOLOGY

  Signaling through CD38 induces NK cell activation