BIOPHYSICAL, MOLECULAR GENETIC AND PHARMACOLOGICAL STUDIES OF PERIODIC PARALYSES AND MYOTONIC SYNDROMES: ETIOPATHOGENESIS AND NOVEL THERAPEUTIC APPROACHES

Pubblicazioni Scientifiche

• 2003 MOLECULAR PHARMACOLOGY

  Different ability of clenbuterol and salbutamol to block sodium channels predicts their therapeutic use in muscle excitability disorders

• 2003 MOLECULAR PHARMACOLOGY

  Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds

• 2004 FASEB JOURNAL

  Carbonic anhydrase inhibitors are specific openers of skeletal muscle BK channel of K+-deficient rats

• 2001 NEUROLOGY

  Gating of myotonic Na channel mutants defines the response to mexiletine and a potent derivative

• 2003 NEUROMUSCULAR DISORDERS

  Involvement of 3Na(+)/2K(+) ATP-ase and Pi-3 kinase in the response of skeletal muscle ATP-sensitive K+ channels to insulin

• 2004 NEUROBIOLOGY OF DISEASE

  The alteration of calcium homeostasis in adult dystrophic mdx muscle fibers is worsened by a chronic exercise in vivo

• 2006 BRITISH JOURNAL OF PHARMACOLOGY

  A new benzoxazine compound blocks KATP channels in pancreatic beta cells: molecular basis for tissue selectivity in vitro and hypoglycaemic action in vivo