PED, A NOVEL GENE CONTROLLING GLUCOSE TRANSPORT IN MAMMALIAN CELLS: ITS ROLE IN TYPE 2 DIABETES

Pubblicazioni Scientifiche

• 2000 MOLECULAR AND CELLULAR BIOLOGY

  Insulin-activated protein kinase C beta bypasses Ras and stimulates mitogen-activated protein kinase activity and cell proliferation in muscle cells

• 2002 JOURNAL OF BIOLOGICAL CHEMISTRY

  Glucose regulates insulin mitogenic effect by modulating SHP-2 activation and localization in JAr cells

• 2002 JOURNAL OF BIOLOGICAL CHEMISTRY

  Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function

• 2004 JOURNAL OF BIOLOGICAL CHEMISTRY

  Protein kinase C-zeta and protein kinase B regulate distinct steps of insulin endocytosis and intracellular sorting

• 2004 JOURNAL OF BIOLOGICAL CHEMISTRY

  Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15

• 2001 CANCER RESEARCH

  Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells

• 2000 DIABETES

  The IR1152 mutant insulin receptor selectively impairs insulin action in skeletal muscle but not in liver

• 2001 JOURNAL OF BIOLOGICAL CHEMISTRY

  Insulin receptor substrate-2 phosphorylation is necessary for protein kinase C zeta activation by insulin in L6hIR cells

• 1998 EMBO JOURNAL

  PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus

• 2001 DIABETES

  Protein kinase C (PKC)-alpha activation inhibits PKC-zeta and mediates the action of PED/PEA-15 on glucose transport in the L6 skeletal muscle cells

• 2002 JOURNAL OF BIOLOGICAL CHEMISTRY

  Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells

• 2001 JOURNAL OF BIOLOGICAL CHEMISTRY

  Activation and mitochondrial translocation of protein kinase C delta are necessary for insulin stimulation of pyruvate dehydrogenase complex activity in muscle and liver cells

• 2003 ONCOGENE

  Protein kinase C alpha activation by RET: evidence for a negative feedback mechanism controlling RET tyrosine kinase

• 2004 MOLECULAR AND CELLULAR BIOLOGY

  Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action

• 1999 JOURNAL OF BIOLOGICAL CHEMISTRY

  In L6 skeletal muscle cells, glucose induces cytosolic translocation of protein kinase C-alpha and trans-activates the insulin receptor kinase