Studio di nuove strategie terapeutiche per l’Atassia di Friedreich

Pubblicazioni Scientifiche

• 2015 HUMAN MOLECULAR GENETICS

  Src inhibitors modulate frataxin protein levels

• 2015 NEUROBIOLOGY OF DISEASE

  Highly specific ubiquitin-competing molecules effectively promote frataxin accumulation and partially rescue the aconitase defect in Friedreich ataxia cells

• 2013 EXPERIMENTAL GERONTOLOGY

  Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans

• 2012 HUMAN MOLECULAR GENETICS

  Interferon gamma upregulates frataxin and corrects the functional deficits in a Friedreich ataxia model