STUDY OF THE MECHANISMS OF AMYLOID FORMATION

Pubblicazioni Scientifiche

• 2001 PROTEIN SCIENCE

  Reduction of the amyloidogenicity of a protein by specific binding of ligands to the native conformation

• 2001 JOURNAL OF BIOLOGICAL CHEMISTRY

  Folding and aggregation are selectively influenced by the conformational preferences of the alpha-helices of muscle acylphosphatase

• 2002 NATURE STRUCTURAL BIOLOGY

  Kinetic partitioning of protein folding and aggregation

• 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME

  Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases

• 2001 PROTEIN SCIENCE

  Solution conditions can promote formation of either amyloid protofilaments or mature fibrils from the HypF N-terminal domain

• 2002 NATURE

  Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

• 2002 ELECTROPHORESIS

  Capillary electrophoresis investigation of a partially unfolded conformation of beta(2)-microglobulin

• 2001 JOURNAL OF BIOLOGICAL CHEMISTRY

  A partially structured species of beta(2)-microglobulin is significantly populated under physiological conditions and involved in fibrillogenesis

• 2001 JOURNAL OF MOLECULAR BIOLOGY

  Detection of two partially structured species in the folding process of the amyloidogenic protein beta 2-microglobulin