THE ROLE OF NEUROMELANN IN AGING AND PARKINSON DISEASE

Pubblicazioni Scientifiche

• 2001 JOURNAL OF NEUROCHEMISTRY

  Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes

• 2003 TRENDS IN NEUROSCIENCES

  Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics

• 2003 FASEB JOURNAL

  Activation of microglia by human neuromelanin is NF-kappa B-dependent and involves p38 mitogen-activated protein kinase: implications for Parkinson's disease

• 2000 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME

  Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles

• 2003 BIOCHEMICAL PHARMACOLOGY

  Iron-binding characteristics of neuromelanin of the human substantia nigra

• 1999 FEBS LETTERS

  The structure of neuromelanin and its iron binding site studied by infrared spectroscopy

• 2000 JOURNAL OF NEUROCHEMISTRY

  Interaction of human substantia nigra neuromelanin with lipids and peptides

• 2002 FEBS LETTERS

  The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's disease

• 2003 JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT

  The neuromelanin of human substantia nigra: structure, synthesis and molecular behaviour