Who we are?
A mixed Immunology / Genomics / Gene Therapy lab at the San Raffaele Scientific Institute in Milan, Italy. Our goal is to decipher how sequence content, chromatin dynamics and transcription factor networks at cis-regulatory elements govern gene expression in the immune system. By doing so, we aim at uncovering novel targets for immunotherapy, as well as general paradigms of transcriptional regulation.
What we do?
Using mouse models, we have just discovered a key regulator of the tumor microenvironment in pancreatic cancer. Therapeutic targeting of this molecule stimulates innate and adaptive immunity, leading to immune-mediated control of tumor growth (unpublished). We are now translating these compelling findings to humans, and have embarked on a large analysis of tumor-infiltrating immune cells in fresh biopsies from primary and metastatic cancer patients. This project entails the generation, integration and computational modelling of data from flow cytometry, single-cell RNA sequencing, spatial transcriptomics and single-cell epigenomics.
What we look for?
A motivated and curious individual with solid background in data analysis and/or quantitative biology. Previous experience in single-cell genomics, immunology or oncology are a plus. We invite applications from scientists at the pre- or post-doctoral level, providing adequate degrees of independence and mentorship.
What we offer?
A competitive salary, commensurate to qualifications and experience; close interactions with a large pool of computational scientists at the Center for Omics Sciences (COSR), biologists and clinicians; a vibrant environment with opportunities for professional growth in one of Europe's leading research and clinical centres.
Send your CV, a cover letter with motivation and research interest, and contact information for 2-3 references at [email protected] (deadline March 31st, 2020)
